Thermo Fisher Scientific SETD1B Polyclonal Antibody

Thermo Fisher Scientific SETD1B Polyclonal Antibody

Applications and Tested Dilution

• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
GLQFVNLPPYR GPFSLSNSGP GRGQHWPPLP KFDPSVPPPG YMPRQEDPHK ATVDGVLLVV LKELKAIMK

Highest antigen sequence identity to the following orthologs:

• Mouse: 97%
• Rat: 97%

Target Information

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA to trigger the immune response. VISA is a mitochondrial membrane protein identified as a critical component in the IFN-β signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA also interacts with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2, and TRAF6. Additionally, VISA interacts with the IKK-α, IKK-β, and IKK-ι kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to evade the host immune system. At least three isoforms of VISA are known to exist.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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