Thermo Fisher Scientific CTSW Monoclonal Antibody (4A8)

Thermo Fisher Scientific CTSW Monoclonal Antibody (4A8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
IRGPLRAQDL GPQPLELKEA FKLFQIQFNR SYLSPEEHAH RLDIFAHNLA QAQRLQEEDL GTAEFGVTPF SDLTEEEFGQ LYGYRRAAGG VPSMGREIRS EEPEESVPFS CDWRKVAGAI SPIKDQKNCN CCWAMAAAGN IETLWRISFW DFVDVSVQEL LDCGRCGDGC HGGFVWDAFI TVLNNSGLAS EKDYPFQGKV RAHRCHPKKY QKVAWIQDFI MLQNNEHRIA QYLATYGPIT VTINMKPLQL YRKGVIKATP TTCDPQLVDH SVLLVGFGSV KSEEGIWAET VSSQSQPQPP HPTPYWILKN SWGAQWGEKG YFRLHRGSNT CGITKFPLTA RVQKPDMKPR VSCPP

Target Information

Cathepsin W (lymphopain) and cathepsin F comprise a novel subgroup of cathepsin proteases, and are phylogenetically distinct from other human cathepsins. The cathepsin W gene maps to chromosome 11q13.1 and contains ten exons with introns ranging from 81–119 bp. Cathepsin W protein is expressed specifically in CD8+ T lymphocytes. The expression of cathepsin W first occurs during the differentiation of thyrocytes to CD8+ T lymphocytes, just as the thymocytes cease expression of CD4+ receptors. In transfected Cos-7 and HeLa cells, cathepsin W localizes within the rough endoplasmic reticulum. Cathepsin W contains a unique 21 amino acid peptide insertion between the active site histidine and asparagine residues, in addition to a distinctive 8-amino acid carboxy-terminal extension. An extended loop structure in the second β-sheet domain and an additional disulfide bond are two of several signature features of cathepsin W. Other features include an additional cysteine, an S2 pocket, and an additional residue. Cathepsin W may exist as a dimer with each monomer forming a disulfide bond.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.