Thermo Fisher Scientific CTSW Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Human: 100%

Target Information

Cathepsin W (lymphopain) and cathepsin F comprise a novel subgroup of cathepsin proteases, phylogenetically distinct from other human cathepsins.
The cathepsin W gene maps to chromosome 11q13.1 and contains ten exons with introns ranging from 81–119 bp.
Cathepsin W protein is expressed specifically in CD8+ T lymphocytes. Expression first occurs during differentiation of thyrocytes to CD8+ T lymphocytes as thymocytes cease expression of CD4+ receptors.
In transfected Cos-7 and HeLa cells, cathepsin W localizes within the rough endoplasmic reticulum.
Cathepsin W contains a unique 21 amino acid peptide insertion between the active site histidine and asparagine residues, and a distinctive 8-amino acid carboxy-terminal extension.
An extended loop structure in the second β-sheet domain and an additional disulfide bond are signature features. Other features include an additional cysteine, an S2 pocket, and an additional residue.
Cathepsin W may exist as a dimer with each monomer forming a disulfide bond.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.