Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (OTI9G8), TrueMAB
TNFRSF18(GITR) 단백질을 인식하는 마우스 단클론 항체. Western blot과 IHC(파라핀 절편)에서 검증됨. 인간 시료에 반응하며, 액상 형태로 제공됨. 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보존. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9G8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 26–162 of human TNFRSF18 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a human protein encoded by the TNFRSF18 gene located on chromosome 1p36.33. This receptor, part of the TNF-receptor superfamily, shows increased expression upon T-cell activation and plays a key role in maintaining immunological self-tolerance via regulatory T cells (CD25⁺CD4⁺). Knockout studies in mice indicate its involvement in CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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