Thermo Fisher Scientific Phospho-SMAD1 (Ser206) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Smad1 only when phosphorylated at Ser206.

Target Information

The protein encoded by this gene belongs to the SMAD family, which includes proteins similar to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways.
This protein mediates the signals of bone morphogenetic proteins (BMPs), which regulate cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, SMAD1 is phosphorylated and activated by the BMP receptor kinase. The phosphorylated form forms a complex with SMAD4, essential for transcriptional regulation.
SMAD1 is also a target for SMAD-specific E3 ubiquitin ligases such as SMURF1 and SMURF2, leading to ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.