Thermo Fisher Scientific CD122 Monoclonal Antibody (1G11H3)
CD122 단백질을 표적하는 Mouse IgG2b 단일클론 항체로, Western blot, Flow cytometry, ELISA에 적합. 정제된 재조합 인간 CD122 단편으로부터 유래. Protein G 정제, 액상 형태, 1 mg/mL 농도. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G11H3 |
| Immunogen | Purified recombinant fragment of human CD122 (AA: extra 27–240) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090775 |
Target Information
CD122 (Interleukin-2 receptor) participates in T cell–mediated immune responses and is mainly expressed in the hematopoietic system. It exists in three forms:
- Low affinity form: Alpha subunit monomer, not involved in signal transduction
- Intermediate affinity form: Alpha/beta heterodimer
- High affinity form: Alpha/beta/gamma heterotrimer
The intermediate and high affinity forms are responsible for receptor-mediated endocytosis and mitogenic signal transduction. The CD122 gene encodes the beta subunit, a type I membrane protein.
Dysfunction of CD122 is associated with diseases such as oligoarticular juvenile idiopathic arthritis and rheumatoid factor–negative juvenile idiopathic arthritis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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