Thermo Fisher Scientific ERN2 Polyclonal Antibody
Thermo Fisher Scientific의 ERN2 Polyclonal Antibody는 Human, Mouse, Rat에 반응하며 Rabbit IgG 기반의 액상 항체입니다. 다양한 IHC, ICC, ELISA 실험에 적합하며 Protein A로 정제되었습니다. ER 스트레스 반응 관련 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ERN2 (amino acids 465–550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ERN2 serine/threonine kinase, also known as endoplasmic reticulum to nucleus signaling 2 protein, is a human homologue of the yeast Ire1 gene product. It plays a role in multiple aspects of the ER stress response in mammalian cells. Unlike closely related proteins, this pro-apoptotic protein appears to play no role in the unfolded-protein response. Overexpression of ERN2 activates BiP and CHOP expression, leading to programmed cell death. Ern2 is suggested to be involved in several facets of the ER stress response in mammalian cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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