Thermo Fisher Scientific GALR2 Polyclonal Antibody

Thermo Fisher Scientific GALR2 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 40 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• Human (100%)
• Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Bovine, Horse (94%)
• Panda, Dog, Bat (89%)

Target Information

GalR2 expression is widely documented in the brain and peripheral tissues such as small intestine, heart, kidney, and liver.
Localization data from rat CNS indicate high levels of expression in dorsal root ganglia, amygdala, and Purkinje neurons.

G-protein Coupled Receptors (GPCRs) form one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices.
They exist in active and inactive forms, with activating ligands inducing conformational changes leading to G-protein signaling.
Negative regulation of GPCRs plays a crucial role in cellular physiology and pharmacological research, with major GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) demonstrating significant therapeutic impact.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.