Thermo Fisher Scientific CD45 Monoclonal Antibody (HI30), PerCP-Cyanine5.5, eBioscience
상품 옵션 정보 | ||||||||
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
45-0459-42 | - | Thermo Fisher Scientific 45-0459-42 CD45 Monoclonal Antibody (HI30), PerCP-Cyanine5.5, eBioscience 100 tests pk | 재고문의 | pk | 570,000원 | - | 627,000원 | |
45-0459-41 | - | Thermo Fisher Scientific 45-0459-41 CD45 Monoclonal Antibody (HI30), PerCP-Cyanine5.5, eBioscience 25 tests pk | 재고문의 | pk | 241,000원 | - | 265,100원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Flow Cytometry (Flow)
5 µL (0.125 µg)/test
View 57 publications 57 publications
Product Specifications
Species Reactivity
Human
Published species
Human, Mouse, Rabbit
Host/Isotype
Mouse / IgG1, kappa
Recommended Isotype Control
Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PerCP-Cyanine5.5, eBioscience™
Class
Monoclonal
Type
Antibody
Clone
HI30
Conjugate
PerCP-Cyanine5.5 PerCP-Cyanine5.5 PerCP-Cyanine5.5
View additional formats
- Unconjugated
- Alexa Fluor 532
- Alexa Fluor 561
- Alexa Fluor 647
- Alexa Fluor 660
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395
- Brilliant UV 496
- Brilliant UV 563
- Brilliant UV 615
- Brilliant UV 661
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 421
- Brilliant Violet 480
- Brilliant Violet 605
- Brilliant Violet 650
- Brilliant Violet 711
- eFluor 450
- eFluor 506
- FITC
- NovaFluor Blue 510
- NovaFluor Blue 585
- NovaFluor Blue 690
- NovaFluor Red 710
- NovaFluor Red 725
- NovaFluor Red 755
- NovaFluor Yellow 590
- NovaFluor Yellow 660
- NovaFluor Yellow 730
- NovaFluor Yellow 755
- PE
- PE-Cyanine5
- PE-Cyanine5.5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Request custom conjugation
Excitation/Emission Max
489/679 nm View spectra
Form
Liquid
Concentration
5 µL/Test
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10718244
Product Specific Information
Description: The HI30 monoclonal antibody reacts with all isoforms of human CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding circulating erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
Applications Reported: This HI30 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This HI30 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488 nm; Emission: 695 nm; Laser: Blue Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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