Thermo Fisher Scientific RIM3 Polyclonal Antibody
인간 RIM3 단백질에 특이적인 토끼 폴리클로날 항체로, ICC/IF에 사용 가능. 액상 형태로 항원 친화 크로마토그래피로 정제됨. 신경 전달 및 시냅스 가소성 연구에 적합. 단기 4°C, 장기 -20°C 보관.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human RIM3. Recombinant protein control fragment (Product #RP-106619) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665101 |
Product Specific Information
- Immunogen sequence: MVAIVGLTQWS KSTLQLPQPE GATKKLRSNI RR
- Highest antigen sequence identity to orthologs: mouse 100%, rat 100%
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neural transmission and plasticity. While RIM1 and RIM2 are known Rab3 effector proteins binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known about RIM3. Expression of RIM3 in PC12 cells induces a significant increase in calcium-triggered exocytosis without affecting baseline release, suggesting a role in exocytosis regulation. RIM3 localizes primarily to neuronal dendrites and postsynaptic densities, unlike RIM1 which is presynaptic, indicating RIM3 may contribute to synaptic transmission and plasticity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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