Thermo Fisher Scientific FAM175B Polyclonal Antibody
Thermo Fisher Scientific의 FAM175B Polyclonal Antibody는 인간 FAM175B 단백질을 인식하는 토끼 유래 다클론 항체로, 세포면역형광(ICC/IF)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼 내에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human FAM175B (Recombinant protein control fragment Product #RP-107971) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2663326 |
Product Specific Information
Immunogen sequence:
VPDLVFLLFSF ISTANNSTHA LEYVLFRPNR RYNQRISLAI PNLGNTSQQE YKVSSVPNTS QSYAKVIKEH GTDFFDKDGV MKDIRAIYQV YNALQE
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
FAM175B is a component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked polyubiquitin, retaining the last ubiquitin on substrates. It acts as a scaffold protein maintaining BRISC components in the cytoplasm and regulates apoptosis by modulating Lys-63-linked ubiquitination. FAM175B is essential for mitotic spindle assembly and kinetochore attachment via deubiquitination of NUMA1. It also regulates interferon signaling through IFNAR1 deubiquitination, stabilizing IFNAR1 and enhancing its activity. Additionally, it down-regulates LPS responses and is required for proper p53 induction following DNA damage, promoting USP7–p53 interaction and preventing p53 degradation.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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