Thermo Fisher Scientific Human APBA2 Synthetic Peptide

Thermo Fisher Scientific Human APBA2 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the amino terminus of human APBA2.
PEP-1167 can be used as a blocking peptide with polyclonal antibody PA5-21053.

Target Information

APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer’s disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimer’s disease patients.
APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
Recent reports suggest that it may also be a candidate gene for autism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.