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Thermo Fisher Scientific ABRO Polyclonal Antibody
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Thermo Fisher Scientific

Thermo Fisher Scientific ABRO Polyclonal Antibody

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Thermo Fisher Scientific의 ABRO 폴리클로날 항체는 인간 FAM175B 단백질의 특정 영역(350–390)을 인식합니다. Western blot 및 immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용되며 4°C에서 보관합니다.

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Thermo Fisher Scientific
카테고리
Polyclonal Antibodies
판매단위
pk

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마지막 업데이트 2025. 08. 05. 오후 07:48
Thermo Fisher Scientific A301255A ABRO Polyclonal Antibody 100 ul pk판매 단위 pk ·
재고 확인 필요
658,900원VAT 포함 724,790원
재고문의·견적요청 옵션은 실시간 상담으로 납기를 확인해 드립니다 · 연구비 카드 결제 가능

Thermo Fisher Scientific · Thermo Fisher Scientific ABRO Polyclonal Antibody

Applications

Western Blot (WB)

  • Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

  • Tested Dilution: 2–5 µg/mg lysate

Product Specifications

항목 내용
Species Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Region between residue 350 and 390 of human abraxas brother 1 (FAM175B, UniProt ID: Q15018-1, NCBI Node ID: 9606)
Conjugate Unconjugated
Form Liquid
Concentration 0.20 mg/mL
Purification Antigen affinity chromatography
Storage Buffer TBS, pH 7.0–8.0, with 0.1% BSA
Contains 0.09% sodium azide
Storage Conditions 4°C
Shipping Conditions Wet ice

Product Specific Information

  • Recommended shelf life: 1 year from date of receipt.

Target Information

ABRO (FAM175B) is a component of the BRISC complex, which specifically cleaves Lys-63-linked polyubiquitin chains while retaining the last ubiquitin on substrates. It acts as a scaffold for BRISC complex assembly and cytoplasmic retention. ABRO is involved in:

  • Regulation of apoptosis via Lys-63-linked ubiquitination.
  • Mitotic spindle assembly and kinetochore attachment through deubiquitination of NUMA1.
  • Interferon signaling via deubiquitination of IFNAR1, enhancing receptor stability and surface expression.
  • Down-regulation of LPS response through IFNAR1 modulation.
  • Induction of p53/TP53 in response to DNA damage by promoting USP7–p53 interaction, leading to p53 stabilization and apoptosis.

Source: UniProt

**For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization._

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