Thermo Fisher Scientific GGCX Polyclonal Antibody
Thermo Fisher Scientific의 GGCX Polyclonal Antibody는 인간 GGCX 단백질을 인식하는 토끼 유래 다클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 항원 친화 정제 방식으로 제조되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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- PA550417
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human gamma-glutamyl carboxylase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635870 |
Product Specific Information
This antibody detects endogenous levels of total GGCX protein.
Target Information
GGCX (gamma-glutamyl carboxylase), also known as GC or VKCFD1 (Vitamin K-dependent gamma-carboxylase), is a 758 amino acid multi-pass membrane protein localized to the membrane of the endoplasmic reticulum.
GGCX mediates the vitamin K-dependent carboxylation of glutamate residues on target proteins, producing calcium-binding gamma-carboxyglutamate (Gla) residues and converting vitamin K to vitamin K epoxide.
It exists as a monomer and modifies glutamate residues to enable the activity of vitamin K-dependent proteins such as blood coagulation and bone matrix proteins.
Defects in the GGCX gene cause combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1) and PXE-like disorder with multiple coagulation factor deficiency, characterized by abnormal skin, blood, or bone function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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