Thermo Fisher Scientific PIGR Polyclonal Antibody
Thermo Fisher Scientific의 PIGR Polyclonal Antibody는 인간 시료에 반응하며 WB, IHC, ICC/IF에 사용 가능합니다. Rabbit IgG 기반의 비결합 항체로, 항원 친화 크로마토그래피로 정제되었습니다. 장기 보관 시 -20°C에서 냉동 보관을 권장합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 180–459 of PIGR (Uniprot ID: P01833) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.39 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11157655 |
Product Specific Information
- Recommended positive controls: Human milk
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Polymeric IgA and IgM are produced and secreted by B cells in the lamina propria, beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors (pIgRs) are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium.
During transport, pIgR undergoes proteolytic cleavage to generate the secretory component (SC), which associates with IgA and IgM to form complexes resistant to enzymatic degradation.
SC and pIgR are essential for mucosal immunity, acting as molecular chaperones for polymeric immunoglobulins. The human SC (pIgR) gene maps to chromosome 1q31–q41 and encodes a 764 amino acid protein comprising five immunoglobulin-like domains and a transmembrane region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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