Thermo Fisher Scientific PCBP2 Recombinant Rabbit Monoclonal Antibody (JE65-05)
Recombinant rabbit monoclonal antibody against PCBP2 (clone JE65-05). Validated for WB and IHC-P. Reacts with human and mouse. Supplied as 1 mg/mL liquid, purified by Protein A. Suitable for cytoplasmic and nuclear protein detection.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE65-05 |
| Immunogen | Synthetic peptide within human PCBP2 aa 251–300/365 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093801 |
Product Specific Information
- Positive control: Jurkat cell lysate, HeLa cell lysate, 293 cell lysate, RAW264.7 cell lysate, human kidney tissue, mouse brain tissue
- Predicted band size: 39 kDa
- Subcellular Location: Cytoplasm, Nucleus
Target Information
The protein encoded by this gene is multifunctional and part of the major cellular poly(rC)-binding proteins along with PCBP-1 and hnRNPK. It contains three K-homologous (KH) domains involved in RNA binding. Together with PCBP-1, it functions as a translational coactivator of poliovirus RNA and promotes viral RNA replication by binding to the 5′-terminal cloverleaf structure. It also plays roles in translational control of 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. Additionally, it contributes to alpha-globin mRNA stability via formation of a sequence-specific mRNP complex. PCBP2 and PCBP1 are paralogs, with related genes PCBP3 and PCBP4 arising from gene duplication events. Two processed pseudogenes (PCBP2P1 and PCBP2P2) are also known. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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