Thermo Fisher Scientific FOXC1 Monoclonal Antibody (1E11)
FOXC1 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 ELISA에 적합합니다. 인간 FOXC1 단백질에 반응하며, 비표지(Unconjugated) 형태로 제공됩니다. PBS buffer에 보관하며 -20°C에서 냉동 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E11 |
| Immunogen | FOXC1 (NP_001444, 464 a.a. approximately 553 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AAHQGRLTSW YLNQAGGDLG HLASAAAAAA AAGYPGQQQN FHSVREFESQ RIGLNNSPVN GNSSCQMAFP SSQSLYRTSG AFVYDCSKF*
Target Information
FOXC1 is a protein belonging to the forkhead family of transcription factors characterized by a distinct DNA-binding forkhead domain. Although the specific function is not fully known, FOXC1 plays a regulatory role in the FGF19-FGFR4-MAPK pathway, contributing to the development and maintenance of anterior segment structures within the eye.
Mutations in this gene are associated with various ocular developmental disorders such as glaucoma, iridogoniodysgenesis anomaly, Peters anomaly (including central corneal leukoma, absence of posterior corneal stroma and Descemet membrane), and Axenfeld-Rieger anomaly (characterized by posterior corneal embryotoxon, iris adhesion to Schwalbe line, hypertelorism, hypoplasia of malar bones, congenital absence of some teeth, and mental retardation).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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