Thermo Fisher Scientific CHM Polyclonal Antibody
Human CHM 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS, 40% 글리세롤 완충액에 보관. 연구용으로만 사용.
- 카탈로그번호
- PA551870
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CHM. Recombinant protein control fragment (Product # RP-92170) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2639770 |
Product Specific Information
Immunogen sequence:
SRKDKTIQHV EVFCYASQDL HEDVEEAGAL QKNHALVTSA NSTEAADSAF LPTEDESLST MSCEMLTEQT PSSDPENALE VNGAEVTGEK ENHCDDKTCV PSTSAEDMSE NVPIAEDTTE QPKKNRITYS QIIKEG
Highest antigen sequence identity to the following orthologs:
- Mouse: 58%
- Rat: 66%
Target Information
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex.
Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B (RABGGTA and RABGGTB).
Remains bound after the geranylgeranyl transfer reaction.
Component A is regenerated by transferring its prenylated Rab back to the donor membrane.
A pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can also bind and prenylate Rab proteins, which is proposed as the predominant pathway for Rab protein geranylgeranylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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