Thermo Fisher Scientific POM121 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Target Information

POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121), or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spliced isoforms and belongs to the POM121 family.
Encoded by a gene that maps to human chromosome 7q11.23, POM121 is highly conserved and localizes to the nuclear membrane and endoplasmic reticulum membrane.
An essential component of the nuclear pore complex (NPC), POM121 is required for nuclear envelope formation and may play a role in the biogenesis of the NPC. It associates with the central spoke ring complex and helps anchor components of the pore complex to the pore membrane via its F-X-F-G repeat-containing domain. Overexpression of POM121 induces the formation of cytoplasmic annulate lamellae (AL).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.