Thermo Fisher Scientific PIAS1 Monoclonal Antibody (ZP008)
PIAS1 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, ICC/IF, ELISA 등에 사용 가능. Human 및 Mouse 반응성 확인. Protein A 정제, 0.5 mg/mL 농도, PBS 버퍼에 0.1% sodium azide 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| ELISA | Assay-dependent | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ZP008 |
| Immunogen | Recombinant protein derived from the internal region of the human PIAS1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533428 |
Target Information
PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and its substrate, and acts as a SUMO-tethering factor. It plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT, p53, and steroid hormone signaling pathways. In testis, PIAS1 functions as a nuclear receptor transcriptional coregulator and may be involved in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation, or silencing may vary depending on biological context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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