Thermo Fisher Scientific LMX1A Polyclonal Antibody
LMX1A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 시료에 반응하며, 고순도 친화 크로마토그래피 정제. PBS/50% 글리세롤 보존, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LMX1A (Accession Q8TE12), corresponding to amino acid residues R152–L202 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900153 |
Product Specific Information
This antibody detects endogenous levels of total LMX1A.
Target Information
The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family, known for roles in developmental pattern formation. LMX1A binds an A/T-rich sequence and acts as a transcriptional activator in the nucleus, regulating the insulin gene promoter. During embryonic development, LMX1A is expressed along the neuraxis and contributes to the formation of the vertebral roof plate. It is essential for the differentiation of dopamine neurons, while its homolog LMX1B supports their development and survival. LMX1A may serve as a biomarker or risk factor in tumor aggressiveness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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