Thermo Fisher Scientific MPP8 Polyclonal Antibody
Thermo Fisher Scientific의 MPP8 Polyclonal Antibody는 인간 MPP8 단백질을 인식하는 토끼 다클론 항체입니다. Western blot, IHC(P), ICC/IF 등에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. H3K9me 관련 후성유전적 억제 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MPP8 (Product #RP-98007) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644083 |
Product Specific Information
Immunogen sequence:
GLEHGFEKPL DSAMSAEEDT DVRGRRKKKT PRKAEDTREN RKLENKNAFL EKKTVPKKQR NQDRSKSAAE LEKLMPVSAQ TPKGRRLSGE ERGLWSTDSA EEDKETKRNE SKE
Sequence identity:
- Mouse: 56%
- Rat: 58%
Target Information
MPP8 is a heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 (H3K9me) and promotes recruitment of proteins mediating epigenetic repression. It recruits the HUSH complex to H3K9me3 sites, maintaining transcriptional silencing by promoting SETDB1-mediated H3K9me3 deposition and MORC2 recruitment. MPP8 also recruits DNMT3A to CpG sites, mediating DNA methylation and repressing CDH1 expression. It collaborates with MORC2 and SETDB1 in silencing L1 retrotransposons and unintegrated retroviral DNA, contributing to epigenetic regulation and transcriptional repression.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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