Thermo Fisher Scientific CHFR Polyclonal Antibody
CHFR 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 ELISA에 적합합니다. Human 및 Mouse 시료에 반응하며, 핵 및 PML body에 위치한 단백질 검출에 유용합니다. Affinity Chromatography로 정제된 고순도 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–290 of human CHFR (NP_001154818.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.8 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804494 |
Product Specific Information
Immunogen sequence:
MERPEEGKQS PPPQPWGRLL RLGAEEGEPH VLLRKREWTI GRRRGCDLSF PSNKLVSGDH CRIVVDEKSG QVTLEDTSTS GTVINKLKVV KKQTCPLQTG DVIYLVYRKN EPEHNVAYLY ESLSEKQGMT QESFDTSGAG AGRGADPRVP PSSPATQVCF EEPQPSTSTS DLFPTASASS TEPSPAGRER SSSCGSGGGG ISPKGSGPSV ASDEVSSFAS ALPDRKTASF SSLEPQDQED LEPVKKKMRG DGDLDLNGQL LVAQPRRNAQ TVHEDVRAAA GKPDKMEETL
Positive Samples: HT-1080, 22Rv1, HepG2, Mouse kidney, Mouse testis
Cellular Location: Nucleus, PML body
Target Information
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosomes move apart from each other along the periphery of the nucleus. Involved in signaling mitotic stress caused by microtubule poisons through mediating Lys-48-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes ubiquitination and degradation of AURKA and PLK1. May act as a tumor suppressor by mediating polyubiquitination of HDAC1. Also promotes Lys-63-linked polyubiquitin chain formation with the UBC13-MMS2 (UBE2N-UBE2V2) complex, which is involved in cellular stress signaling.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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