Thermo Fisher Scientific Human Fibrinogen Native Protein

Applications

• Control (Assay-dependent)

Publications

• Miscellaneous PubMed: 2 publications available

Product Specifications

Product Specific Information

• RP-43142 contains native human Fibrinogen protein.
• May be used as a positive control in various immunological assays.
• Product is derived from human blood/plasma origin.
• Starting material tested and found negative/nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore, and anti-HTLV I & II.
• Handle with caution due to potential testing margin of error.
• For in vitro research use only. Not intended for clinical or diagnostic use.

Target Information

Fibrinogen, the precursor of fibrin, is a coagulable protein in vertebrate blood plasma. After vascular injury, thrombin cleaves fibrinogen to form fibrin, the major component of blood clots.
Fibrinogen is a dimer of three pairs of non-identical chains (FGA, FGB, FGG) cross-linked by disulfide bonds in their N-terminal regions. It contains two terminal D domains and one central E domain, which separate upon degradation by plasmin.
Mutations in the fibrinogen gene can cause disorders such as dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.