Thermo Fisher Scientific Importin 4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Importin 4. Recombinant protein control fragment (Product #RP-97613). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Importin 4,uniProtId:Q8TEX9-1,ncbiNodeId:9606,antigenRange:690-773,antigenLength:1081,antigenImageFileName:PA5-58634_Importin_4_Q8TEX9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58634_Importin_4_Q8TEX9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642714

Product Specific Information

Immunogen sequence: AFLPYMESVF EEVFKLLECP HLNVRKAAHE ALGQFCCALH KACQSCPSEP NTAALQAALA RVVPSYMQAV NRERERQVVM AVLE

Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 77%.

Target Information

Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.