Thermo Fisher Scientific POLG Polyclonal Antibody
POLG 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 Affinity 정제, 1 mg/mL 농도, PBS/glycerol buffer에 저장. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human POLG (Accession P54098), corresponding to amino acid residues Y452–K502 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853124 |
Product Specific Information
Antibody detects endogenous levels of total POLG1.
Target Information
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic.
Defects in this gene are associated with:
- Progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1)
- Sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO)
- Alpers-Huttenlocher syndrome (AHS)
- Mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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