Thermo Fisher Scientific PIF1 Polyclonal Antibody
인간 PIF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC(P)에서 1:20~1:100 희석으로 사용 가능. DNA 복제 및 텔로미어 유지 연구에 적합. 액상 형태, -20°C 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PIF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2688407 |
Target Information
PIF1 is a single-stranded (ss) DNA-dependent ATPase and DNA helicase that unwinds DNA in a 5′ to 3′ direction relative to the bound strand. It plays a critical role in DNA replication and telomere length maintenance in Saccharomyces cerevisiae. The PIF1 gene is highly conserved from yeast to humans. Mutations in PIF1 lead to telomere lengthening, indicating its function as a catalytic inhibitor of telomere formation and elongation. Human PIF1 preferentially binds telomeric DNA and inhibits telomerase activity. It counteracts RecQ homolog Sgs1 helicase activity, and its degradation is mediated by the ubiquitin–26S proteasome pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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