Thermo Fisher Scientific NKG2C Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
CAVLQVNRLKS AQCGSSMIYH CKH

Highest antigen sequence identity to the following orthologs:

• Mouse: 38%
• Rat: 38%

Target Information

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity.
The protein encoded by this gene belongs to the killer cell lectin-like receptor family (NKG2 family), a group of transmembrane proteins preferentially expressed in NK cells. This family is characterized by type II membrane orientation and the presence of a C-type lectin domain.
This protein forms a complex with KLRD1/CD94 and is implicated in the recognition of MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12.
Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.