Thermo Fisher Scientific SF3A1 Monoclonal Antibody (OTI2C4), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500

Product Specifications

Target Information

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2, and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing.
Subunit 1 belongs to the SURP protein family, characterized by SURP motifs that mediate RNA binding. It has tandemly repeated SURP motifs in the amino-terminal half and a proline-rich region with a ubiquitin-like domain in the carboxy-terminal half.
Binding studies indicate that the two SURP motifs are essential for interaction with subunit 3, while contacts with subunit 2 occur through sequences carboxy-terminal to the SURP motifs.
Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: TA800587_SF3A1_Q15459-1_House_mouse.svg, TA800587_SF3A1_Q15459-1_House_mouse_PDP.jpeg)