Thermo Fisher Scientific HDAC9 Monoclonal Antibody (OTI5B8)
HDAC9 단백질을 특이적으로 인식하는 Thermo Fisher Scientific의 단클론 항체입니다. Western blot 및 IHC(P) 실험에 최적화되어 있으며, 고순도 액상 형태로 제공됩니다. 인간 시료 반응성이 높고 안정적인 보관이 가능합니다.
- 카탈로그번호
- MA526727
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 181–460 of HDAC9 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724427 |
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a critical component of transcriptional regulation, and histone acetylation plays a major role in this process. Acetylation of lysine residues in histones leads to conformational changes that enhance DNA accessibility to transcription factors. Mammalian histone acetylases include GCN5, PCAF, p300/CBP, HAT1, and TAF II p250. Conversely, histone deacetylation is associated with transcriptional silencing. The histone deacetylases (HDAC) family includes HDAC1–9. HDAC9 and HDAC9a are alternatively spliced isoforms, both retaining catalytic activity and repressing MEF2-mediated transcription. They are expressed in brain, skeletal muscle, kidney, placenta, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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