Thermo Fisher Scientific GATM Monoclonal Antibody (OTI1C9), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

AGAT (glycine amidinotransferase, also known as GATM or transamidinase) is a 423-amino acid enzyme belonging to the amidinotransferase family.
Encoded on human chromosome 15q21.1, AGAT forms a homodimer that localizes to mitochondrial inner membranes, peripheral membranes, and cytoplasm.
It is expressed in various tissues including brain, heart, liver, lung, salivary gland, skeletal muscle, and kidney (high expression).
AGAT catalyzes the biosynthesis of guanidinoacetate, a precursor of creatine, essential for energy metabolism in muscle.
Defects in AGAT are linked to arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay, mental retardation, and reduced brain creatine levels.
AGAT may play roles in embryonic and CNS development and in heart failure response via local creatine synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.