Thermo Fisher Scientific POLR3C Monoclonal Antibody (OTI2H1)

Applications and Tested Dilution

Product Specifications

Target Information

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
POLR3C may interact with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via interactions between TFIIIB and POLR3F.
It may be involved in recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation.
POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It acts as a nuclear and cytosolic DNA sensor involved in the innate immune response.
POLR3C can sense non-self dsDNA that serves as a template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB through the RIG-I pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.