Thermo Fisher Scientific POLR3C Polyclonal Antibody
Thermo Fisher Scientific의 POLR3C Polyclonal Antibody는 인간 POLR3C 단백질을 인식하는 고품질 항체로, WB 및 IHC(P) 응용에 적합합니다. Rabbit IgG 폴리클로날 타입이며, Protein A로 정제된 액상 제품입니다. 연구용으로 DNA/RNA 전사 및 면역반응 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:400
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human POLR3C (amino acids 50–80) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
POLR3C is a specific core component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs.
POLR3C may interact with other members of the subcomplex RNA Pol III and the TFIIIB-DNA complex via interactions between TFIIIB and POLR3F.
It may be involved in recruitment and stabilization of the subcomplex within RNA polymerase III or in stimulating catalytic functions during initiation.
POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.
It acts as a nuclear and cytosolic DNA sensor involved in innate immune response, detecting non-self dsDNA and inducing type I interferon and NF-κB through the RIG-I pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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