Thermo Fisher Scientific PDZ-GEF1 Polyclonal Antibody
PDZ-GEF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot, IHC, IP에 사용 가능. 액상 형태로 제공되며 4°C에서 보관. 세포 신호전달 연구 및 Rap/Ras GTPase 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | — |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 | Epitope retrieval with citrate buffer pH 6.0 or Tris-EDTA pH 9.0 recommended for FFPE tissue sections |
| Immunoprecipitation (IP) | Assay-dependent | — |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 975 and 1025 of human PDZ domain containing guanine nucleotide exchange factor (GEF) 1 (RAPGEF2, UniProt ID: Q9Y4G8-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 or Tris-EDTA pH 9.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Dog
Target Information
PDZ-GEF1 functions as a guanine nucleotide exchange factor (GEF) that activates Rap and Ras family small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. It links cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades and acts as an effector for Rap1 by direct association with Rap1-GTP, amplifying Rap1-mediated signaling. Shows weak activity on HRAS.
It participates in cAMP-induced Ras and Erk1/2 signaling pathways leading to inhibition of melanogenesis and promotes apoptosis in melanoma cells. Also involved in neuron migration, axon outgrowth, and regulation of endothelial junction integrity during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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