Thermo Fisher Scientific Cyclin B1 Recombinant Rabbit Monoclonal Antibody (23GB1670)
Cyclin B1 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot, ICC/IF, Flow cytometry 등 다양한 응용에 적합합니다. HEK293F 시스템에서 발현되었으며, 고순도의 액상 형태로 제공됩니다. 세포주기 연구 및 암 관련 단백질 분석에 활용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB1670 |
| Immunogen | A synthesized peptide derived from human Cyclin B1 (1–200AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Cyclins bind to and regulate the activity of Cyclin-dependent protein kinases (CDKs). Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis and is essential for controlling the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF).
Two alternative transcripts have been found: one constitutively expressed and another predominantly expressed during G2/M phase. Cyclin B1 accumulates during G2 phase and is abruptly degraded at the end of mitosis through APC-dependent destruction, which is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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