Thermo Fisher Scientific ATM Recombinant Rabbit Monoclonal Antibody (3G11)

Applications and Tested Dilution

Product Specifications

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer. The ATM gene encodes a protein in the phosphoinositide 3-kinase (PI3K) superfamily that phosphorylates proteins rather than lipids, regulating downstream targets such as P53, Mdm2, BRCA1, and SMC1.

ATM plays a critical role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. Its C-terminal region shows homology to catalytic domains of PI3 kinases. Upon exposure to ionizing radiation, ATM becomes autophosphorylated and upregulated. Cells deficient in ATM are hypersensitive to radiation, show impaired DNA synthesis inhibition, and delayed p53 induction. DNA damage activates ATM kinase, initiating a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA repair. ATM is also linked to apoptosis through interactions with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.