Thermo Fisher Scientific PSMB7 Monoclonal Antibody (OTI4E3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Target Information

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure composed of four rings of 28 non-identical subunits: two rings of seven alpha subunits and two rings of seven beta subunits. Proteasomes are distributed throughout eukaryotic cells at high concentrations and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
A modified proteasome, the immunoproteasome, processes class I MHC peptides.
The gene encodes a member of the proteasome B-type (T1B) family, a 20S core beta subunit. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.