Thermo Fisher Scientific CD43 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive Control: Human thymus tissue lysates, human tonsil tissue, human spleen tissue, Jurkat cells.

Target Information

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with a high negative charge, expressed on the surface of most hematopoietic cells. It contributes to a repulsive barrier that interferes with cellular adhesion but can also promote leukocyte aggregation in certain contexts.
Through interactions with actin-binding proteins ezrin and moesin, CD43 plays a regulatory role in remodeling T-cell morphology and modulates cell-cell interactions during lymphocyte trafficking.
CD43 signaling enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 induces functionally active tumor suppressor p53 protein; however, in p53 and ARF deficiency, CD43 promotes tumor proliferation and viability.
Diseases associated with CD43 dysfunction include Wiscott–Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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