Thermo Fisher Scientific CD43 Polyclonal Antibody
인간 CD43 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, Flow Cytometry에 적합합니다. 고순도 Affinity Chromatography 정제, 1 mg/mL 농도, PBS/glycerol buffer로 안정적 보관. 면역세포 표면 CD43 연구용으로 활용.
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- PA5109343
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human CD43 aa 351–400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854754 |
Product Specific Information
Positive Control: Human thymus tissue lysates, human tonsil tissue, human spleen tissue, Jurkat cells.
Target Information
CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with a high negative charge, expressed on the surface of most hematopoietic cells. It contributes to a repulsive barrier that interferes with cellular adhesion but can also promote leukocyte aggregation in certain contexts.
Through interactions with actin-binding proteins ezrin and moesin, CD43 plays a regulatory role in remodeling T-cell morphology and modulates cell-cell interactions during lymphocyte trafficking.
CD43 signaling enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 induces functionally active tumor suppressor p53 protein; however, in p53 and ARF deficiency, CD43 promotes tumor proliferation and viability.
Diseases associated with CD43 dysfunction include Wiscott–Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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