Thermo Fisher Scientific CAMSAP3 Polyclonal Antibody
Rabbit polyclonal antibody against human CAMSAP3. Validated for IHC (Paraffin) with dilution 1:50–1:200. Recognizes microtubule minus-ends, regulating their dynamics and organization. Supplied as liquid, 0.1 mg/mL, in PBS with 40% glycerol and 0.02% so...
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CAMSAP3. Recombinant protein control fragment (Product # RP-98884) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2639261 |
Product Specific Information
Immunogen sequence:
LRHQPILMGA HLAVIDALMA AFAFEWTKTL PGPLALTSLE HKLLFWVDTT VRRLQEKTEQ EAAQRASPAA PADGAAPAQP SIRYRKDR
Sequence identity:
- Mouse: 93%
- Rat: 92%
Target Information
CAMSAP3 is a key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. It recognizes growing microtubule minus-ends, stabilizes microtubule lattices, and protects them from depolymerization. CAMSAP3 is required for zonula adherens biogenesis and maintenance by anchoring microtubule minus-ends and recruiting kinesin KIFC3. It orients apical-to-basal microtubule polarity in epithelial cells, plays essential roles in early embryonic development, and links microtubules to actin filaments through interaction with MACF1, influencing focal adhesion and cell migration. CAMSAP3 also contributes to organelle organization, including the Golgi and early endosomes, and participates in Golgi vesicle translocation via interaction with AKAP9.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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