Thermo Fisher Scientific ATG12 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: ATG12.

Target Information

ATG12, a member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy.
This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells.
ATG12 interacts with ATG10 in human embryonic kidney cells in the presence of ATG7.
At least two isoforms of ATG12 are known to exist.
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells.
It preserves cellular nutrients under starvation conditions and regulates cytosolic component turnover.
This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.