Thermo Fisher Scientific MUC1 Monoclonal Antibody (OTI3A7), TrueMAB
인간 MUC1 단백질을 인식하는 단클론 항체로, Western Blot, IHC, ICC/IF에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 보존. 연구용으로만 사용되며, 암 관련 MUC1 발현 연구에 유용합니다.
- 카탈로그번호
- TA800938
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A7 |
| Immunogen | Full length human recombinant protein of human MUC1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is a transmembrane glycoprotein with a large extracellular domain, processed through proteolysis and addition of numerous O-linked glycans that are heavily sialylated.
MUC1 is highly polymorphic, with alleles encoding different numbers of tandem repeats (30–90), resulting in variable molecular weights. It is abundantly expressed in over 90% of breast carcinomas and metastases.
Transgenic MUC1 associates with all four cebB receptors and localizes with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several alternatively spliced variants. Overexpression and altered glycosylation of MUC1 are linked to carcinoma progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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