Thermo Fisher Scientific NDRG1 Polyclonal Antibody
Thermo Fisher Scientific의 NDRG1 Polyclonal Antibody는 인간 및 다양한 종에 반응하는 Goat IgG 기반 항체로, WB 및 IHC 분석에 적합합니다. 합성 펩타이드 항원으로 제작되었으며, 고순도 액상 형태로 제공되어 연구용 단백질 발현 및 질병 관련 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Dog |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (GNSAGPKSMEVSC) corresponding to the C-terminus amino acids of NDRG1 (aa 382–394) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981733 |
Product Specific Information
- Predicted to react with canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
NDRG1 is a 394 amino acid cytoplasmic protein belonging to the NDRG family. It interacts with APO A-I and A-II and plays a role in HDL-mediated cholesterol transport, stress responses, hormone responses, cell growth, and differentiation.
Defects in NDRG1 cause Charcot-Marie-Tooth disease type 4D (CMT4D), characterized by reduced nerve conduction velocities, segmental demyelination, remyelination with onion bulb formations, progressive distal muscle atrophy, weakness, absent deep tendon reflexes, and hollow feet.
NDRG1 serves as a marker of differentiation and plays a growth inhibitory role. It is expressed in placental membranes, prostate, kidney, small intestine, ovary, colon, and luminal border cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-18109_NDRG1_Q92597-1_Goat.svg, PA5-18109_NDRG1_Q92597-1_Goat_PDP.jpeg)
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