Thermo Fisher Scientific Sortilin Polyclonal Antibody
Sortilin 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB 및 IHC에 사용 가능. Rat Sortilin의 세포외 도메인 합성 펩타이드를 면역원으로 제작. 동결건조 형태로 제공되며, 4°C 또는 -20°C에서 안정적으로 보관 가능. 연구용으로만 사용.
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Thermo Fisher Scientific Sortilin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the extracellular domain of rat Sortilin conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1960719 |
Product Specific Information
Reconstitute with 100 µL of distilled water.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
It is required for protein transport from the Golgi apparatus to lysosomes via a pathway independent of the mannose-6-phosphate receptor (M6PR), and for transport to endosomes.
Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB).
It also acts as a receptor for neurotensin.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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