Thermo Fisher Scientific UNG Monoclonal Antibody (OTI1A6), TrueMAB
Thermo Fisher Scientific의 UNG Monoclonal Antibody (OTI1A6)은 Human UNG 단백질을 인식하는 Mouse IgG1 항체입니다. Western blot에 최적화되어 있으며, 고순도의 Affinity chromatography로 정제되었습니다. PBS/BSA/glycerol 버퍼에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A6 |
| Immunogen | Full-length human recombinant UNG protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.58 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These forms arise from alternative splicing and the use of two differentially regulated promoters (PA and PB).
UNG1 and UNG2 cDNAs are similar in size (2061 and 2058 bp), making them indistinguishable in gel electrophoresis. Nuclear UNG2 differs from mitochondrial UNG1 by 44 amino acids in the N-terminal sequence, which is not required for catalytic activity.
UNG gene products repair mutagenic U:G mispairs caused by cytosine deamination; for example, UNG2 removes misincorporated dUMP residues. Expression levels of UNG1 and UNG2 vary by cell and tissue type and are regulated by the cell cycle. Generally, UNG expression is higher in proliferating than in non-proliferating cells.
UNG1 is a 304 amino acid protein, while UNG2 is 313 amino acids long.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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