Thermo Fisher Scientific CEP164 Monoclonal Antibody (13)
CEP164 단백질을 인식하는 Mouse 모노클로날 항체로, Western blot, ICC/IF, IP에 사용 가능. Human 시료에 반응하며 단백질 G로 정제된 액상 형태. HeLa 세포를 양성 대조군으로 사용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | |
| Immunocytochemistry (ICC/IF) | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 13 |
| Immunogen | Human CEP164 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735144 |
Product Specific Information
- Positive Control: HeLa
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
CEP164 was initially identified as a centrosomal protein, but other studies have indicated that it also plays a role in the formation of primary cilia — the microtubule-based sensory antennae projecting from the surface of many eukaryotic cells — as well as in the DNA damage response acting as a mediator protein.
CEP164 interacts with both ATR and ATM, proteins that trigger a number of cellular responses including the initiation of DNA damage-induced cell cycle checkpoints.
It is phosphorylated upon replication stress, ultraviolet (UV) radiation, and ionizing radiation. Silencing of CEP164 significantly reduces the DNA damage-induced phosphorylation of several proteins in the DNA damage-activated signaling cascade and compromises cell survival after UV damage.
At least two isoforms of CEP164 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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