Thermo Fisher Scientific CEP164 Monoclonal Antibody (13)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Control: HeLa
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

CEP164 was initially identified as a centrosomal protein, but other studies have indicated that it also plays a role in the formation of primary cilia — the microtubule-based sensory antennae projecting from the surface of many eukaryotic cells — as well as in the DNA damage response acting as a mediator protein.
CEP164 interacts with both ATR and ATM, proteins that trigger a number of cellular responses including the initiation of DNA damage-induced cell cycle checkpoints.
It is phosphorylated upon replication stress, ultraviolet (UV) radiation, and ionizing radiation. Silencing of CEP164 significantly reduces the DNA damage-induced phosphorylation of several proteins in the DNA damage-activated signaling cascade and compromises cell survival after UV damage.
At least two isoforms of CEP164 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.