Thermo Fisher Scientific PRKACA Monoclonal Antibody (X2)
PRKACA 단백질을 인식하는 Thermo Fisher Scientific의 Mouse 모노클로날 항체(X2). Western blot과 ELISA에 적합하며, Human 시료에서 반응. 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | X2 |
| Immunogen | PRKACA (AAH39846, 1–120 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WESPAQNTAH LDQFERIKTL GTGSFGRVML VKHKETGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVKLEFS FKDNSNLYMV
Target Information
Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation, and behavior.
PKA is composed of two catalytic (PKAc) and two regulatory (PKAr) subunits. Upon binding cAMP, the complex dissociates into a PKAr dimer and two activated PKAc ser/thr kinase monomers.
The released PKAc can translocate into the nucleus and regulate activation of multiple nuclear hormone receptors. PKAc-mediated activation of tonicity-dependent gene expression is cAMP-independent.
Humans express three PKAc subunit types:
- PKAc alpha (present in most tissues)
- PKAc beta
- PKAc gamma (testes-specific)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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