Thermo Fisher Scientific PSMB7 Monoclonal Antibody (OTI1D1)
PSMB7 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. Human, Mouse, Non-human primate에 반응하며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제 및 안정적 보관 용이.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 58–277 of PSMB7 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.23 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723528 |
Target Information
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core consists of four rings of 28 non-identical subunits: two rings of seven alpha subunits and two rings of seven beta subunits. Proteasomes are widely distributed in eukaryotic cells and are responsible for peptide cleavage in an ATP/ubiquitin-dependent, non-lysosomal pathway.
A modified form, the immunoproteasome, processes class I MHC peptides. The PSMB7 gene encodes a member of the proteasome B-type (T1B) family, a 20S core beta subunit. Its expression is downregulated by gamma interferon, and proteolytic processing is required for maturation. This subunit is absent in the immunoproteasome, replaced by catalytic subunit 2i (proteasome beta 10 subunit).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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