Thermo Fisher Scientific YAP1 Monoclonal Antibody (2F12)
YAP1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse monoclonal antibody (Clone 2F12). Western blot과 ELISA에 적합하며, Human 시료 반응성. Hippo signaling pathway 연구용으로 사용. 액상 형태, 보존제 없음, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F12 |
| Immunogen | YAP1 (NP_006097, 53–161 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QIVHVRGDSE TDLEALFNAV MNPKTANVPQ TVPMRLRKLP DSFFKPPEPK SHSRQASTDA GTAGALTPQH VRAHSSPASL QLGAVSPGTL TPTGVVSGPA ATPTAQHLR
Target Information
YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, functioning as a transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP acts as both a coactivator and corepressor and is a critical downstream regulatory target in the Hippo signaling pathway, which controls organ size and tumor suppression by restricting proliferation and promoting apoptosis. It also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene result in coloboma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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