Thermo Fisher Scientific IL-1 alpha Polyclonal Antibody

Applications

ELISA (ELISA)

• Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

• PA1-75178 specifically detects IL-1 alpha.
• Successfully used in ELISA applications.
• Immunogen: Recombinant IL-1α.

Target Information

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both shared with IL-1 beta. The IL1A gene is located on chromosome 2q13.

IL-1 alpha plays a key role in innate host defense by inducing other proinflammatory cytokines and initiating acute-phase responses. Its activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), which blocks receptor binding through competitive inhibition.

This cytokine is involved in immune responses, inflammation, and hematopoiesis. It is produced as a proprotein by monocytes and macrophages, processed upon cell injury, and can induce apoptosis. IL1A and related interleukin genes form a cytokine cluster on chromosome 2. IL-1 alpha regulates NF-κB and MAPK pathways, stimulates IL6 and COX-2 (PTGS2) expression, and enhances nitric oxide (NO) production.

Elevated IL-1 alpha levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.