Thermo Fisher Scientific PHKB Polyclonal Antibody
PHKB 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, 인간·마우스·랫트 반응성을 가집니다. WB, IHC, ICC, ELISA, IP 등 다양한 응용에 적합하며, Protein A로 정제된 액상 형태로 제공됩니다. -20°C에서 보관하며 연구용으로만 사용됩니다.
- 카탈로그번호
- BS-4032R
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific PHKB Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
| Immunoprecipitation (IP) | 1–2 µg |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human PHKB (amino acids 45–160) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA and 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Phosphorylase kinase is a hexadecameric enzyme composed of four copies of four subunits (PHKA, PHKB, PHKG, PHKD). This serine/threonine-specific kinase converts glycogen phosphorylase b to glycogen phosphorylase a, facilitating the release of glucose-1-phosphate from glycogen.
PHKB (Phosphorylase b kinase regulatory subunit beta) is a 1093-amino-acid regulatory subunit of phosphorylase kinase. Mutations in the PHKB gene cause glycogen storage disease type 9B (phosphorylase kinase deficiency of liver and muscle), characterized by mild hepatomegaly, slightly elevated transaminase and plasma lipids, no clinical muscle involvement, and gradual improvement with age.
Four isoforms of PHKB are produced through alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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